Review On Role of Nanotechnology in Development of Silver Nanoparticle

The vast majority of new molecular entities (NMEs) taken to full-scale development have poor physicochemical and biopharmaceutical properties, which lead to poor pharmacokinetics, poor biodistribution and higher toxicity after administration into living subjects. The critical elements of such NMEs being translated into successful therapeutic agents are therefore optimization of preformulation strategies, rational design of advanced drug delivery systems to accelerate successful translation of these NMEs into clinically useful therapies. Nanoparticulate drug delivery systems have come up to address these limitations by controlling biopharmaceutical behavior and pharmacokinetic profiles and by providing site-specific delivery and low non-specific toxicity. Other than the use of nanotechnology in pharmaceuticals, nanotechnology has transformed various industries around the globe, including agriculture, food and medicine, automobiles, civil engineering and environmental control. Its application in the industry has increased efficiency, productivity, material performance, and sustainability, which reflect its wide spectrum effects, not only in research on the laboratory scale. Nanotechnology in the biomedical field has been particularly promising in the oncology field, in particular in the diagnosis and treatment of oral cancer, which is a highly aggressive malignancy with high morbidity, mortality, and recurrence rates. The traditional diagnostic and treatment modalities lack specificity and have many negative effects. Due to the special physicochemical characteristics and surface modification, nanoparticles provide better diagnostic sensitivity, targeted delivery of specific drugs, and lowered systemic toxicity. This review identifies important parameters and assessment strategies to be used in nanoparticulate drug delivery systems at the early stages of formulation development with a sharp concentration on the application of the systems to the diagnosis and treatment of oral cancer. In addition, it talks about the existing issues, clinical opportunities and future trends of nanotechnology-based interventions with the focus on their role in changing the way cancer is managed, so as to achieve safer, more effective and patient-friendly methods of managing the disease