1,2,3- Triazole Derivatives as Antitubercular Agents

Tuberculosis is a contagious infectious disease with moderately high mortality worldwide. The data shows that around three million people all over the world die yearly from tuberculosis, and there are around eight million new cases each year, out of which developing countries are the main segment. Therefore, the finding and development of effective antituberculosis drugs with novel mechanisms of action have become a persistent task for infectious disease research work. The literature indicates that heterocyclic moieties have garnered significant attention from chemists, pharmacologists, microbiologists, and other researchers due to their considerable biological potential as anti-infective agents. Triazoles, including 1,2,3-triazole and 1,2,4-triazole, are one of the most important classes of nitrogen-containing heterocycles that exhibit various biological activities. Triazole derivatives are regarded as a new class of effective anti-TB candidates owing to their potential anti-TB potency. Thus, molecules containing a triazole moiety may show promising in vitro and in vivo anti-TB activities and might be able to prevent drug resistance to a certain extent. This review outlines the advances in the application of triazole-containing hybrids as anti-TB agents and discusses the structure-activity relationship of these derivatives.