Autism Pathway Framework: A Research Tool for Pathway-Based Analysis of Genetic Heterogeneity in ASD

A comprehensive research framework for pathway- and network-based analysis of genetic heterogeneity in Autism Spectrum Disorder (ASD). The framework shifts the unit of analysis from individual genes to biological pathways, enabling: Integration of genetic variation into pathway-level disruption scores Network-based signal refinement using gene-gene interactions Unsupervised learning to identify biologically coherent subgroups Validation gates with negative controls and stability testing RESEARCH USE ONLY - This framework is for hypothesis generation only. Not for clinical decision-making.