Biological Information Preservation as a Strategy Against Aging: Toward the Engineering of Time-Stable Cellular Systems

This article proposes a paradigm shift from the traditional "damage accumulation" model of aging to an information-centric theory. It posits that aging is fundamentally driven by the progressive corruption and loss of coherent biological information required to maintain cellular identity and systemic coordination. The framework conceptualizes the cell as a multi-layered, non-equilibrium information-processing system, where longevity depends on preserving fidelity across genomic, epigenetic, proteomic, and metabolic layers. The review argues that interventions should aim not merely at repairing molecular damage, but at stabilizing biological information, leading to the engineering of time-stable cellular systems. This unifying perspective explains the reversibility seen in reprogramming and regeneration, and provides a cohesive rationale for diverse gerotherapeutic strategies, from epigenetic resetting to senolysis, under the singular goal of combating informational entropy.