Yatrogenesis/PIT-Topological-Primacy: Topological Informational Primacy v1.0.0

PIT - Topological Informational Primacy v1.0.0 Core Axiom In every physical system, topological changes PRECEDE and CAUSE metric changes. Mathematical Formulation lim(N->inf) P(t_topo < t_metric | transition) = 1 Key Results Molecular Scale (TDA-CUSUM): N=900: 100% precursor detection rate Persistence entropy collapses before crystallization Galactic Scale (MOND Derivation): a0 = cH0/(2pi) derived from topology Error vs observed: ~10% Cosmological Scale (Mobius): CMB anti-correlation: Z = -6.08 sigma CMB x LIGO cross-correlation: Z = 4.31 sigma Falsifiability If ANY system shows t_metric < t_topo robustly, PIT is FALSE. Author Francisco Molina-Burgos Avermex Research Division Merida, Yucatan, Mexico January 2026