aminforouzandehmehr/Forouzandehmehr2026-hiPSC-CMs-Model: hiPSC-CMs Electro-Mechano-Energetic Model (JMCC PLUS 2026)

This release provides the first stable version of the computational model used in: W. Li, M.A. Forouzandehmehr, D. McLeod, M.R. Pozo, Y.W. Heinson, M.W. Kay, Z. Li, S. Morotti, E. Entcheva, Response of human iPSC-cardiomyocytes to adrenergic drugs assessed by high-throughput pericellular oxygen measurements and computational modeling, J. Mol. Cell. Cardiol. Plus 2026;100834. https://doi.org/10.1016/j.jmccpl.2026.100834. Overview This repository contains a MATLAB implementation of an integrated human iPSC-derived cardiomyocyte (hiPSC-CM) model that couples: Membrane electrophysiology Calcium handling Myofilament tension generation Pericellular oxygen consumption rate (OCR) linked to excitation-contraction coupling Contents Core ODE model (hiMCES2026) Integration and simulation scripts Post-processing and biomarker extraction utilities Example protocols for control and pharmacological simulations Citation If you use this code, please cite the associated manuscript and this Zenodo release.