The Red Rebellion: How Lactagard Broke the Blood's Oath

LACTAGARD is the brand of CEFOPERAZONE +SULBACTUM is a third generation cephalosporin antibiotic, beta lactamase inhibitor. Usually gastrointestinal, hematologic, hepatic, hypersensitivity, local, and coagulation related is common Adverse drug reaction caused by this drug, In this case, Hemolytic anemia is caused for the elder patient and it should be monitored closely; if it is not recognized/managed promptly, it can progress to life threatening multiorgan complications. A 94-year-old male patient was admitted with complaints of Fever on &off for 4 days, h/o Breathlessness for 4 days, and h/o Cough with sputum. He has a past history of valvular heart disease - S/P AVR and known case of Systemic hypertension on regular treatment with T.ECOSPIRIN 150 mg , T. ATROVASTATIN 10mg, T.METOPROLOL 25 mg, T.LOSARTAN 25 mg. The Red blood cell Haemoglobin, Packed cell volume, and Red cell distribution width level was normal in level and after administration of LACTOGARD, the Haematology level was decreased in level .The Haematology level was decreased day by day so the drug stopped and the drug was changed to CEFUROXIME AXETIL.A Probable relationship was indicated by the causality score of , which was determined by applying the Naranjo scale.This LACTOGARD is the brand of CEFOPERAZONE +SULBACTUM might result from the rare adverse effects because it destroy the Red blood cell before fully matured by its own immune system it leads to Hemolytic anemia. Optimizing patient safety requires ongoing re-evaluation of therapy