ANTIPLATELET PROPERTIES OF MUMIE: AN IN VITRO STUDY OF PLATELET AGGREGATION

Platelet aggregation plays a central role in hemostasis and thrombosis, and modulation of platelet function is an important therapeutic target. Natural substances with antiplatelet properties are of increasing scientific interest. Platelet aggregation was studied in vitro using platelet-rich plasma. Aggregation was induced by sodium adenosine diphosphate (ADP). Mumie was tested at concentrations of 0.1 and 0.3 mg/mL. Heparin, acetylsalicylic acid, ε-aminocaproic acid, and sodium lagosol were used as reference compounds. Platelet aggregation time was recorded, and results were expressed as mean ± SEM. Statistical significance was assessed in comparison with control samples. Mumie significantly prolonged platelet aggregation time at both tested concentrations, indicating a marked inhibition of platelet aggregation (p < 0.05). The effect was concentration-dependent and comparable to that of acetylsalicylic acid and heparin. Heparin demonstrated the strongest antiaggregatory effect at higher concentrations, while ε-aminocaproic acid showed moderate inhibition. Sodium lagosol exhibited the weakest antiplatelet activity.