INFLUENCE OF MUMIYO EXTRACT ON PLATELET-MEDIATED HEMOSTASIS IN DOGS

Platelets play a key role in primary hemostasis and blood coagulation. The present study investigated the effect of mumiyo extract on platelet count in dogs in order to clarify its contribution to the anticoagulant mechanism of this substance. Clinically healthy dogs were administered mumiyo extract orally at doses of 10, 25, and 50 mg/kg body weight. Platelet counts were determined before administration and at 1 and 2 hours after dosing. The results suggest that reduction of platelet number contributes to the anticoagulant action of mumiyo by affecting platelet-mediated hemostasis. Modulation of platelet count may therefore represent an important mechanism underlying the hypocoagulant effects of mumiyo.