CONTEMPORARY WEIGHT LOSS MEDICATIONS: "A COMPREHENSIVE REVIEW ON THE THERAPEUTIC EFFICACY, SAFETY AND ADVERSE EFFECTS."

This article critically evaluates and understands the weight loss medications or anti-obesity medicines to apprise the modern and traditional medication’s safety, efficacy and the side-effects or ADRs. An excessive build-up of body fat is the hallmark of obesity, which is a long-term metabolic disorder that can have a detrimental impact on a person's body and increase their risk of developing certain chronic illnesses. This can be determined by examining the Body Mass Index (BMI), which normally equals 30 kg/m2, according to the World Health Organization (WHO). Around the world, about 2 billion people are obese. Some unpredictable lifestyle changes, such as sleeping too little, consuming too many calories, and taking medications with weight-gaining side effects, can cause it. To address this problem, a few pharmacological agents or biologically active drugs have been approved by the United state food and drug administration (USFDA) and European medicines agency (EMA). Among these drugs are Orlistat, Phentermine/Topiramate, Lorcaserin, Naltrexone/Bupropion, and Liraglutide. Constipation and nausea are both possible side effects of these medications. One of the natural substances used to reduce weight is Curcumin. through a combination of medication, moderate physical activity, and dietary modifications. The side effects of all these medications can be decreased once treatment is discontinued.