Nipah Virus Outbreak in West Bengal, India (2025-2026): A Comparative Analysis of Pandemic Risk Factors and Public Health Response

Background:In December 2025, India reported two confirmed cases of Nipah virus (NiV) infection in the state of West Bengal, prompting international concern and heightened surveillance measures across Asia. This outbreak occurred amid increased global awareness of pandemic threats following the COVID-19 pandemic, raising questions about NiV’s pandemic potential. Methods:A comprehensive epidemiological analysis of the West Bengal outbreak was conducted, examining case characteristics, contact tracing outcomes, and public health response measures. A comparative risk assessment evaluated NiV against SARS-CoV-2 (COVID-19) across key pandemic determinants, including case fatality rate (CFR), basic reproduction number (R₀), transmission mechanisms, and healthcare system responses. Results:The outbreak involved two healthcare workers, with epidemiological evidence suggesting nosocomial transmission. Among 196 traced contacts, all tested negative and remained asymptomatic, indicating successful containment. NiV exhibits a high CFR (40–75%) but a low R₀ (