Physiologically based pharmacokinetic/ pharmacodynamic (PBPK/PD) model of dulaglutide

This repository provides the dulaglutide physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model: the subcutaneous absorption of dulaglutide with its bioavailability, its distribution into the interstitial space, its protein catabolism and its effects on the fasting plasma glucose, the HbA1c and the body weight in type 2 diabetes. If you have any questions or problems please open an issue Funding Matthias König was supported by the Federal Ministry of Research, Technology and Space (BMFTR, Germany) within ATLAS by grant number 031L0304B and by the German Research Foundation (DFG) within the Research Unit Program FOR 5151 QuaLiPerF (Quantifying Liver Perfusion-Function Relationship in Complex Resection - A Systems Medicine Approach) by grant number 436883643 and by grant number 465194077 (Priority Programme SPP 2311, Subproject SimLivA). This work was supported by the BMBF-funded de.NBI Cloud within the German Network for Bioinformatics Infrastructure (de.NBI) (031A537B, 031A533A, 031A538A, 031A533B, 031A535A, 031A537C, 031A534A, 031A532B).