ANALYTICAL APPROACHES TO THE THERAPEUTIC MODULATION OF INFLAMMATORY AND DEGENERATIVE ORAL MUCOSAL PROCESSES ASSOCIATED WITH REMOVABLE DENTAL PROSTHESES

Resume. Inflammatory and degenerative alterations of the oral mucosal tissues represent one of the most frequently encountered adverse events in individuals rehabilitated with removable dental prosthetic devices, including both partial and complete dentures. The pathogenesis of these lesions is multifactorial and arises from the interplay of persistent mechanical microtrauma, disruption of the commensal oral microbiota, dysregulation of local immunological responses, and biochemical modifications within the denture-bearing substrates. Contemporary therapeutic concepts emphasize restoration of epithelial homeostasis, suppression of inflammatory mediators, and enhancement of patient comfort and prosthesis tolerance without compromising functional performance.Recent experimental and clinical evidence has underscored the therapeutic potential of phytogenic adjuvants such as Calendula officinalis extract, which exhibits pronounced anti-inflammatory, antioxidant, antimicrobial, and immunomodulatory activities. Integration of these biologically oriented and multimodal treatment strategies provides a robust framework for the clinical management of denture-associated oral mucosal disorders, ultimately contributing to improved functional rehabilitation, enhanced patient satisfaction, and superior quality-of-life outcomes. Keywords: oral mucosal disorders; removable dental prostheses; denture stomatitis; inflammatory degeneration; epithelial restitution; prosthetic adaptation; phytotherapeutic adjuvants; Calendula officinalis extract.