EVALUATION OF THE ANTIULCER ACTIVITY OF METHANOLIC EXTRACT OF THE LEAVES OF SAPONARIA OFFICINALIS IN RATS

The present study evaluates the antiulcer activity of the methanolic extract of Saponaria officinalis leaves in rats. The plant material was extracted using methanol and subjected to preliminary phytochemical screening, which indicated the presence of saponins, flavonoids, tannins, and phenolic compounds. Antiulcer activity was assessed using standard experimental models such as ethanol-induced and pylorus ligation–induced gastric ulcers in Wistar albino rats. Parameters including ulcer index, gastric pH, acidity, and mucosal protection were evaluated. The extract showed a significant dose-dependent reduction in ulcer index and gastric acidity, along with enhanced gastric mucosal protection when compared to the control group. The findings suggest that Saponaria officinalis possesses promising gastroprotective and antiulcer potential. Keywords: Saponaria officinalis, Antiulcer activity, Methanolic extract, Rats, Phytochemicals, Gastroprotection.