PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR COACTIVATOR-1Α'S FUNCTION IN HEART ISCHEMIA

Cardiovascular disease remains one of the principle cause of death in both developed and developing countries. It may present as a typical myocardial infarction. Increase in cardiac workload impairs myocardial flow and when oxygen supply becomes inadequate to maintain the prevailing work load, relative ischemia develops and this condition is called Myocardial Infarction. Peroxisome proliferator-activated receptor coactivator-1α (PGC-1 α) is a master regulator of oxidative metabolism and mitochondrial function. PGC-1α lacks DNA-binding activity but interacts with nuclear receptors such as peroxisome proliferated activated receptors (PPARs) and co-activates numerous transcription factors like nuclear respiratory factors (NRFs) and estrogen related receptors (ERRs) that are involved in mitochondrial biogenesis, energy metabolism, fatty acid oxidation, antioxidant activity and angiogenesis. Keywords: Myocardial Infarction, PGC-1 α, PPAR, NRF, ERR