FireGate Biotech FG-003: In Silico Systems Analysis Supporting a Coordinated Neuro-Immune Repair Axis

We performed an in silico systems-level functional association and enrichment analysis using the STRING database to assess whether a curated FG-003 neuro-immune repair gene/protein set forms a coherent non-random network. The analysis demonstrates highly significant protein–protein interaction enrichment and dense connectivity linking inflammatory signaling (IL-1/inflammasome), microglial identity programs, and oligodendrocyte lineage and myelination-associated biology. These results support a coordinated mechanistic rationale for FG-003 as a multi-axis strategy integrating inflammation control with remyelination support.