Autonomic–Cardiovascular Allostasis Under Sustained CB1 Signalling

Autonomic and cardiovascular regulation depend on adaptive flexibility rather than static set points. This paper examines how sustained CB1 signalling biases regulatory dynamics toward sympathetic dependence, reduces recovery capacity, and increases vulnerability to electrical and perfusion instability. Risk is framed as loss of physiological resilience over time, particularly in populations with reduced adaptive reserve. The work is descriptive and intended to support state-aware reasoning in ECS-related research and clinical interpretation.