RETROSPECTIVE EVALUATION OF DRUG THERAPY PROBLEMS IN CKD-ESRD PATIENTS AT CONNAUGHT TEACHING HOSPITAL COMPLEX – FREETOWN

Background: Chronic kidney disease (CKD), especially end-stage renal disease (ESRD), is complexed with polypharmacy, causing drug therapy problems (DTPs), including adverse reactions, inappropriate doses, and interactions that add to morbidity and healthcare expenses. The purpose of this study was to determine, DTPs of hospitalized CKD patients using a standardized taxonomy Methods: This retrospective study investigated drug therapy problems in hospitalized CKD-ESRD patients. A range of eligible records (n=98) available from the Records unit of Connaught Hospital Teaching Complex hospital were examined (January 2022-December 2024). Patients with documented drug therapy, aged 10 years and above were included. A structured questionnaire was used to identify and classify DTPs based on the patient needs domain of Indication, Effectiveness, Safety, and Adherence. The demographics, DTP prevalence and actions were summarized using descriptive statistics; inferential statistics were done using chi-square tests, correlation, ANOVA, t-tests and regressions (SPSS v.25, p