Nanoemulsion-Based Delivery of Centella Asiatica: Formulation, Characterization, And Antioxidant Efficacy

Centella asiatica (CA), a traditional medicinal herb rich in triterpenoids such as asiaticoside, madecassoside, asiatic acid, and madecassic acid, has been widely explored for its pharmacological properties, particularly its antioxidant, wound healing, neuroprotective, and anti-aging effects. However, poor solubility, limited permeability, and chemical instability of its bioactive constituents hinder therapeutic efficacy in conventional formulations. Nanoemulsion-based delivery systems offer a promising approach to overcome these challenges by enhancing solubility, stability, skin penetration, and bioavailability. This review provides a comprehensive overview of CA phytochemistry, pharmacology, and limitations of traditional delivery, followed by an in-depth analysis of nanoemulsion formulation strategies, characterization methods, and antioxidant efficacy assessments. Comparative advantages over conventional formulations, limitations, regulatory considerations, and future perspectives are also discussed. Collectively, the review highlights nanoemulsion-based systems as an advanced platform for unlocking the therapeutic potential of CA in pharmaceutical and cosmeceutical applications.