Renal Tissue Damage and Urea Level Due to of Mefenamic Acid (500 Mg) In Laboratory Rats (Rattus Norvigicus)

Non-steroidal anti-inflammatory drugs (NSAIDs) represent a class of chemically diverse agents with analgesic, antipyretic, and anti-inflammatory effects. The cyclooxygenase enzymes catalyzing the first step in prostanoid biosynthesis are predominantly inhibited by them. Differences in NSAID efficacy and safety might be explained via relative selectivity for the COX-2 or COX-1 enzyme. This results in reduced prostaglandin synthesis, which has both undesirable and good effects. COX-1 is present in the kidneys, stomach, platelets, and intestines by default, but COX-2 is inducible through inflammation in the brain, vascular endothelium, joints, kidneys, and reproductive tract. This research was done to evaluate the effect of mefenamic acid (500 mg) on male rats’ kidneys. 12 males wistar rats 8- week aged, (190 ± 20 gm) body weight was used, divided into two groups, treatment group and control group, former were dosed daily for a week at dose of (643± 10µ) of mefenamic acid syrup, which approximately equivalent to the dose of adult (500 mg / 70 kg), the results showed histopathological changes in kidney like, bleeding, vacuolation, glomerulosclerosis, renal tubules damage.