Formulation And Evaluation of Transdermal Patches from Thespesia Populnea for Anti-Inflammatory Activity

Thespesia populnea Linn belongs to the Malvaceae family. The average height ranges from 10 meters [20 to 33 feet], has glossy green heart-shaped leaves, and yellow hibiscus-like flowers. The plant contains a wide variety of biologically active substances, including Sugars, Antioxidants, Tannins, Sesquiterpenoids, Flavonoids, Alkanes and Essential oils. This plant includes phytochemical constituents that are responsible for anti-bacterial, anti-diarrhoeal, anti-diabetic, memory-boosting, anti-inflammatory, anti-oxidant, and wound-healing activity.A transdermal drug delivery system (TDDS) offers a better route for drug delivery. It is known that drugs from herbal origin, when incorporated into transdermal patches, improve the efficacy. Transdermal patches are medicated adhesive pads that release the medicament over a period of time for several hours at a constant rate. The medicament is directly released into the bloodstream and thereby avoids first-pass metabolism. These patches were assessed using Physicochemical criteria, including pH, Thickness, and Moisture content, Weight uniformity, Folding Endurance, Physical Appearance, and an In-vitro drug release and Stability Study.