Design and Evaluation of Furosemide Matrix Tablets Using Solid Dispersion Technique for Enhanced Oral Bioavailability

The objective of this study is to enhance the oral bioavailability of furosemide by the development and evaluation of furosemide matrix tablets that are made using the solid dispersion technique. Following the manufacture of furosemide solid dispersions by the use of solvent evaporation and kneading techniques, the solubility, drug content, and practical yield of these dispersions were evaluated. PVP K-30 was used as the hydrophilic carrier. On the other hand, the solubility of SDS3 (1:2 ratio, solvent evaporation) was about four times higher than that of pure furosemide, coming in at 0.2746 mg/ml. In order to obtain a sustained release of the medicine, matrix tablets were filled with solid dispersions that were tuned and then polymerized with xanthan gum. All of the tablets' physical characteristics, including their hardness, friability, weight uniformity, thickness, and drug content, were examined, and it was discovered that they met all of the pharmacopeial requirements. In agreement with the models that were presented by Higuchi and Korsmeyer-Peppas, the kinetic analysis suggested that the release was regulated by diffusion. Furthermore, the in-vitro dissolution experiments demonstrated that the release was maintained for a period of fifteen to twenty-four hours. The findings of this study demonstrate that the combination of the matrix tablet formulation with the solid dispersion method has the potential to significantly enhance the controlled release and solubility of furosemide products. Consequently, this has the potential to boost the oral bioavailability of the medication as well as its therapeutic efficacy.