USP deubiquitinase function is likely required in the human embryo during differentiation to the trophectoderm.
Abstract
We measured total transcription in the inner cell mass (ICM) and the trophectoderm (TE) of the human embryo to understand the mechanisms underlying TE commitment. We describe here identification of deubiquitinases from the USP family as lineage commitment cooperating molecules in embryonic stem cells of the human embryo.
Fields of Study & Subjects
Pluripotent Stem Cells Research
Developmental Biology and Gene Regulation
Epigenetics and DNA Methylation
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 4 February 2026
- Document type
- Preprint