Stabilization of Amorphous Biologics via Geometric Frustration in Mesoporous Silica: Mechanistic Insights for Rescuing Pharmacokinetically Flawed Therapeutics

This paper details a stimuli-responsive 'Vimana' architecture designed to stabilize fragile biologics through nanoconfinement-induced geometric frustration. By integrating a phyllosilicate thermal mantle with a piezoelectric cyclosilicate resonator, we demonstrate a solid-state vehicle capable of maintaining amorphous stability under high-heat stress (>50°C) and achieving magneto-acoustic triggered release. This mineral-based platform provides a hierarchical mechanical intervention to rescue 'Lazarus' compounds—therapeutics with high biological efficacy but prohibitive pharmacokinetic flaws.