Development and Validation of Analytical Method for Assay of Carbimazole Tablet

The detector response of Carbimazole is linear in the concentration range from 10.071mcg/mL to90.641 mcg/mL i.e. 20% to 180% level. The % RSD of six replicate injections of standard solution indicates an acceptable level of precision.The% RSD value indicates an acceptable level of precision for the assay results. Hence it is concluded that the assay method is precise. The % RSD value indicates an acceptable level of precision for the assay results. Hence it is concluded that the assay method is precise and reproducible The analytical method meets the pre-established acceptance criteria for accuracy study as per protocol. Hence it is concluded that the assay method is accurate. Based upon above results it is concluded that the standard and test solution are stable up to 35hrs and 36 hrs respectively at 10ºC.Based upon above results it is concluded that the assay method is robust for change in flow rate, change in column oven temperature, change in change inorganic content in mobile phase for Carbimazole tablets 5mg and 20mg.Based on above study it is concluded that 0.45µm PVDF filter and 0.45µm Nylon filter is found to be suitable for both standard and sample solution for filtration.