Interpretable Machine Learning of Nonlinear EEG Dynamics Enables Robust Differentiation of Alzheimer's Disease and Frontotemporal Dementia
Abstract
This repository contains the complete computational pipeline for the study titled “Interpretable EEG-based classification of Alzheimer’s disease and frontotemporal dementia using nonlinear dynamics and explainable machine learning.” The project develops and validates a transparent machine learning framework to distinguish Alzheimer’s disease (AD), behavioral variant frontotemporal dementia (FTD), and healthy controls (HC) using resting-state electroencephalography (EEG). The methodology emphasizes nonlinear dynamic features (e.g., recurrence quantification, Lyapunov exponents, multiscale entropy) and model interpretability via SHAP and topographic mapping.
Fields of Study & Subjects
EEG and Brain-Computer Interfaces
Dementia and Cognitive Impairment Research
Artificial Intelligence in Healthcare
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 5 February 2026