Overcoming the Round Window Barrier: A Critical Review of Nanocomposite In-Situ Gels for Inner Ear Therapy
Abstract
The escalating global prevalence of inner ear disorders, particularly Sensorineural Hearing Loss (SNHL) and Meniere’s Disease (MD), presents a critical public health challenge, with over 430 million people affected worldwide. Current pharmacotherapies are severely limited by anatomical barriers: the Blood-Labyrinth Barrier (BLB) blocks systemic drug delivery (>99% drug exclusion), while standard intratympanic injections fail due to rapid drainage via the Eustachian tube (
Fields of Study & Subjects
Advanced Drug Delivery Systems
Hearing
Cochlea
Tinnitus
Genetics
Vestibular and auditory disorders
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 6 February 2026
- Language
- EN