In neonates undergoing screening for Congenital Adrenal Hyperplasia (CAH), does second-tier 17-OHP quantification using LC-MS/MS improve diagnostic specificity compared with traditional radioimmunoassay?
Abstract
LC-MS/MS as a second-tier test improves the specificity and positive predictive value of CAH screening in neonates, reducing the incidence of false positives associated with traditional immunoassay methods.
Fields of Study & Subjects
Sexual Differentiation and Disorders
Metabolism and Genetic Disorders
Adrenal Hormones and Disorders
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 7 February 2026