Control-State Gate Hypothesis of Metastatic Cancer: A Systems-Level Phase Transition in Organismal Regulation
Abstract
This work proposes the Control-State Gate Hypothesis of metastatic cancer, suggesting that lethal cancer progression may require a prior systems-level transition in organismal physiological regulation rather than arising solely from cumulative cellular mutation. The framework predicts that metastasis-permissive states emerge from distributed neural and neuro-immune regulatory remodeling, reduced adaptive physiological flexibility, and altered system-level control dynamics. Clear falsifiable predictions
Fields of Study & Subjects
Cancer
Stress
Anesthesia
and Immune Response
Cancer Cells and Metastasis
Mathematical Biology Tumor Growth
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 7 February 2026
- Language
- EN
- Document type
- Preprint