A Cell Division–Synchronized State Restoration Model

Cellular aging is commonly viewed as an irreversible accumulation of entropy linked to repeated cell divisions. Traditional strategies aimed at avoiding this process have focused on either extending divisions indefinitely or halting division entirely, but these approaches carry fundamental limitations — increased oncogenic risk or loss of regenerative capacity. Here, we propose a closed-loop control model in which, instead of altering division itself, the state of a cell is restored to an initial reference following each discrete division event. In this framework, aging-like effects are defined not as problems to be removed but as increments of entropy that must be compensated after each division. We model cellular state as an event-driven process and demonstrate theoretically that division‑synchronized state restoration can satisfy conditions for long-term maintenance of cellular function. This framework extends beyond traditional paradigms centered on unlimited division or division arrest, offering a novel concept for maintaining stability amid repeated divisions.