HORDB 2.0

Peptide hormones (or peptide hormones) are key signaling molecules secreted by endocrine cells, regulating vital processes such as metabolism, growth, development, and reproduction. Advances in protein detection and machine learning continue to reveal novel peptide hormones, highlighting their potential in clinical applications and drug development.To support systematic research, we have upgraded HORDB to version 2.0, an open-access, manually curated database of peptide hormones. It comprises 7,390 entries, including 7307 peptide hormones and 83 peptide hormone drugs, which correspond to 372 marketed formulations. Each entry is annotated with sequence, activity, structure, physicochemical properties, patents, clinical data, and references. Additional parameters such as IC₅₀, EC₅₀, ED₅₀, and blood–brain barrier permeability are included to aid peptide modification and drug design.The database features a user-friendly interface for browsing, searching, and downloading data. A submission portal enables community updates, and integrated tools support online analysis of peptide properties and functions. HORDB 2.0 serves as a comprehensive and practical resource for peptide hormone research and therapeutic development.