A Review on Estimation of Ciprofloxacin in Pharmaceuticals Dosage Form

Ciprofloxacin is a member of the fluoroquinolone family, which has biological activity against both gram-positive and gram-negative bacteria. Given the high rate of resistance brought on by other antibiotics, the aforementioned medication is quite important. Numerous studies have been conducted to find ciprofloxacin and its metabolites because of their importance in the drug's biological activity. Liquid chromatography, gas chromatography, capillary electrophoresis, and other separation techniques were used to create, adapt, and implement analytical procedures for the drug analysis. For the Ciprofloxacin assay for quality control, biological fluids, animal tissues, and various sample types, other research used the hyphenation between liquid chromatography and mass spectrometry. In order to estimate ciprofloxacin and its combination of drugs, this review discusses various analytical techniques such as UV spectrophotometry, chromatographic techniques such as High Performance Liquid Chromatography (HPLC), Ultra Performance Liquid Chromatography (UPLC), High Performance Thin Layer Chromatography (HPTLC), and hyphenated techniques such as Liquid Chromatography-Mass Spectroscopy (LC-MS), Ultra Performance Liquid Chromatography-Mass Spectroscopy (UPLC-MS). This review clarifies the ideal conditions for estimating ciprofloxacin.