Supplementary material for the paper "Design Evaluation and Optimization in Nonlinear Mixed-Effect Models in R: The PFIM Package"

These files accompany the paper "Design Evaluation and Optimization in Nonlinear Mixed Effects Models in R: The PFIM Package" and provide practical illustrations of how to use the PFIM package for optimal experimental design in pharmacometrics. Two ZIP files containing the supplementary material for the PFIM package vignettes: design evaluation and continuous and discrete optimization examples. Each ZIP contains R scripts, data ans results needed to reproduce the examples from the vignettes.