Hidden Origins of Modern Autoimmunity: Polyethoxylated Pattern Mimicry and Anti-PEG Antibodies

Anti-PEG IgM antibodies, as part of the natural polyreactive repertoire, may predispose to autoimmune initiation by amplifying early innate responses against repetitive endogenous structures exposed during tissue inflammation. Although current evidence remains preliminary—largely based on in vitro binding data and vaccine reactogenicity observations—their high baseline prevalence and documented boosting after widespread PEG exposure since 2020 raise the possibility that they function as a modern environmental bridge between repetitive synthetic exposure and early immune-mediated tissue damage.