TERF1 repression as a component of the TE differentiation signature in human iPS cells suggests differences in telomerase dynamics between pluripotent stem cells and the TE.
Abstract
We measured total transcription in the inner cell mass (ICM) and the trophectoderm (TE) of the human embryo to understand the mechanisms underlying TE commitment. We describe here identification of TERF1 as a cooperating factor in lineage commitment embryonic stem cells of the human embryo.
Fields of Study & Subjects
Pluripotent Stem Cells Research
Developmental Biology and Gene Regulation
Telomeres
Telomerase
and Senescence
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 9 February 2026
- Document type
- Preprint