Kinetically programmed myosin activation and repression during differentiation to the trophoectoderm in human embryonic stem cells.
Abstract
We measured total transcription in the inner cell mass (ICM) and the trophectoderm (TE) of the human embryo to understand the mechanisms underlying TE commitment. We describe here discovery of a kinetically patterned myosin activation and repression program during differentiation to the trophoectoderm in human embryonic stem cells with functions in lineage commitment.
Fields of Study & Subjects
Pluripotent Stem Cells Research
Developmental Biology and Gene Regulation
Genomics and Chromatin Dynamics
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 9 February 2026
- Document type
- Preprint