Sp6 and SPIB regulation in the human embryo during lineage specification to the TE.
Abstract
We measured total transcription in the inner cell mass (ICM) and the trophectoderm (TE) of the human embryo to understand the mechanisms underlying TE commitment. We describe here identification of Sp6 and SPIB as lineage commitment cooperating factors in embryonic stem cells of the human embryo.
Fields of Study & Subjects
Pluripotent Stem Cells Research
Developmental Biology and Gene Regulation
Epigenetics and DNA Methylation
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 9 February 2026
- Document type
- Preprint