Zic3 is the major imprinting factor active in the TE commitment processes.
Abstract
We measured total transcription in the inner cell mass (ICM) and the trophectoderm (TE) of the human embryo to understand the mechanisms underlying TE commitment. We describe here discovery of Zic3 as a lineage commitment factor or lineage commitment cooperating factor in embryonic stem cells of the human embryo. Zic3 was the major imprinting factor active in the TE commitment processes, where it functioned with histone methyltransferase KMT2E.
Fields of Study & Subjects
Developmental Biology and Gene Regulation
Pluripotent Stem Cells Research
Genetic Syndromes and Imprinting
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 9 February 2026
- Document type
- Preprint