Chalcones: A Review on Multiple pharmacological activities

Chalcones are simple structural compounds that occur naturally and have been widely used in medicinal chemistry to develop drugs with potential therapeutic applications. This article reviews the synthesis methods, physicochemical properties, and structural variations of chalcones. It also discusses their preparation techniques and a range of biological activities, such as antibacterial, anti-inflammatory, anticancer, and antioxidant effects, with emphasis on structure–activity relationships. Chalcone derivatives continue to attract the interest of medical researchers due to their easy synthesis, simple chemical nature, ease of hydrogen modification, and diverse biological activities. Despite their significant potential as chemical precursors for developing new and effective drugs, chalcones have not yet received the level of recognition they deserve.