Clinical Efficacy of Vitamin D3 Supplementation in the Elderly: A Systematic Review

Abstract Introduction: Vitamin D plays a fundamental role in maintaining the homeostasis of the human organism, acting in an integrated way in the skeletal, muscular, immune, and metabolic systems. Objective: To systematically evaluate the available scientific evidence on the clinical efficacy of vitamin D3 supplementation in the elderly. Methods: This study constitutes a systematic review, classified as exploratory and descriptive. The research was conducted using bibliographic research in electronic databases on methods associated with SLR (Systematic Literature Review) and the applications of SMARTER (Simple Multi-Attribute Rating Technique using Exploiting Rankings). Results: A comprehensive systematic literature search yielded a total of 167 articles related to the topic addressed; of these, 24 articles became eligible to compose this systematic review. Conclusion: This systematic review allowed for a critical analysis of the available scientific evidence regarding the clinical efficacy of vitamin D3 supplementation in elderly individuals, considering different clinical, functional, and metabolic outcomes. Keywords: Vitamin D; Nutritional Supplements; Elderly; Effectiveness