Hypospadias: A Comprehensive Review of Etiology, Classification, Diagnosis, and Management

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Authors: Meesala Gowthami, Ramanathan Bhargav*, Arutla Alekhya, M. Nikhitha
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Abstract

In boys, hypopadias is a congenital anomaly that affects 0.2 to 4.1 out of every 1000 live births and is distinguished by an improper position of the urethral opening. It is caused by faulty fusion of the urethral folds during pregnancy, which can lead to other issues such as urinary difficulties and penile curvature. The various types of hypopadias include glanular, coronal, subcoronal, midshaft, penoscrotal, scrotal/perineal, distal, proximal, and hypospadias cripple, which vary in severity depending on where the meatus is located. Effective therapy typically includes surgical correction to address functional and cosmetic concerns; the diagnosis is often made prior to birth. The disorder has a complex etiology that includes genetic and environmental factors, with an incidence rate of approximately 1 in 250 males. To avoid the condition's consequences, early detection and treatment are critical. Boys with hypopadias, a common congenital disorder, have an improperly positioned urethral entry, incomplete foreskin development, and a bent penile. It is caused by aberrant urethral and penile development in the fetus, particularly between weeks 8 and 14. Hypospadias is categorized into three types based on the position of the urethral openings: anterior, middle, and posterior. The sickness can be caused by a variety of factors, including hormonal and hereditary. Unusual urine streams and curvature are clinical signs that may indicate long-term problems. Clinical diagnosis is typically associated with other problems. Surgical correction is required to ensure functional and cosmetic normality, and is typically performed within 6 to 18 months. With proper administration, this treatment produces good results. Hypopadias requires multidisciplinary treatment as well as regular monitoring.

Fields of Study & Subjects

Urological Disorders and Treatments Pediatric Urology and Nephrology Studies Congenital Anomalies and Fetal Surgery

Publication details

Journal / source
International Journal of Medical & Pharmaceutical Sciences
Publication date
10 February 2026
Language
EN