Bingobin/ClinDnaVar_NF: ClinDnaVar_NF v1.0.0

Release Overview This is the initial stable release of ClinDnaVar_NF, a Nextflow-based bioinformatics pipeline designed for high-sensitivity detection and interpretation of Clonal Hematopoiesis (CH) variants. This release supports the methodological framework described in our recent review, focusing on error-corrected sequencing and clinical-grade variant filtering. Key Features Nextflow Core: Fully containerized (Docker/Singularity) and portable workflow for reproducible genomic analysis. UMI-Based Error Suppression: Implements consensus calling for ultra-deep sequencing data to minimize technical noise in low-VAF variant detection. Multi-Caller Integration: Supports standardized variant calling across multiple complementary tools to improve accuracy. CH-Specific Filtering: Integrated logic for filtering CH-associated somatic mutations and distinguishing them from germline variants or sequencing artifacts. Academic Transparency In alignment with open science principles, this release provides the complete analytical methodology utilized in our study to ensure independent verification and reproducibility.