What is the recommended dosage and timing for administering mesna for hemorrhagic cystitis prophylaxis in patients receiving cyclophosphamide?
Abstract
Mesna is generally administered at 20% of the cyclophosphamide dose, with doses given 15-30 minutes before and 4 and 8 hours after cyclophosphamide, to prevent hemorrhagic cystitis.
Fields of Study & Subjects
Chemotherapy-induced organ toxicity mitigation
Chemotherapy-related skin toxicity
Bladder and Urothelial Cancer Treatments
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 11 February 2026
- Language
- EN