Formulation and Evaluation of Niosomal Foot Crack Gel using Pomegranate Peel

Cracked heels (foot fissures) are a common dermatological condition associated with dryness and susceptibility to infection. Conventional topical treatments often show limited effectiveness due to poor skin penetration. The present study aimed to formulate and evaluate a herbal niosomal gel containing pomegranate (Punica granatum L.) peel extract for the management of foot cracks. Niosomes were prepared using the ether injection method with non-ionic surfactants and cholesterol and incorporated into a Carbopol 940-based gel. The formulation was evaluated for vesicular characteristics and physicochemical parameters, including pH, viscosity, homogeneity, spreadability, washability, and skin irritation. The study emphasizes the potential of niosomal gel systems to enhance topical delivery of herbal actives and provide controlled drug release, offering a promising alternative to conventional topical formulations for cracked heels.