Hemodynamic and Clinical Outcomes of Impella-Assisted High-Risk Percutaneous Coronary Interventions in Patients with Severe Left Ventricular Dysfunction and Complex Coronary Anatomy: A Retrespective Registry-Based Investigation

This study examines the hemodynamic and clinical outcomes of Impella-assisted high-risk percutaneous coronary interventions (HR-PCI) in patients presenting with severe left ventricular dysfunction and complex coronary artery disease. Utilizing a retrospective registry-based design, the investigation analyzes real-world procedural and post-procedural data. The research primarily evaluates the ability of Impella mechanical circulatory support to maintain hemodynamic stability during complex coronary interventions, particularly in patients with reduced ejection fraction, multivessel disease, left main involvement, or heavily calcified lesions. Key outcomes include procedural success rates, peri-procedural complications, hemodynamic improvement, and short- and long-term clinical endpoints, such as mortality, rehospitalization, and progression of heart failure. The study aims to determine whether Impella support enhances procedural safety and improves clinical outcomes in high-risk patient populations, contributing to the optimization of revascularization strategies in individuals with advanced cardiac dysfunction.