HLA and HCG expression guides immune activation in utero during TE commitment.
Abstract
We measured total transcription in the inner cell mass (ICM) and the trophectoderm (TE) of the human embryo to understand the mechanisms underlying TE commitment. We describe here identification of genes of the major histocompatibility (MHC) family as lineage commitment cooperating factors in embryonic stem cells of the human embryo. The HLA-DRB family class II receptor was a component of the TE transition, as was HCG15.
Fields of Study & Subjects
Pluripotent Stem Cells Research
Developmental Biology and Gene Regulation
Reproductive System and Pregnancy
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 11 February 2026
- Language
- EN
- Document type
- Preprint