HES6 and HEY1, along with DLL1 form a Notch transcriptional network in the trophectoderm.
Abstract
We measured total transcription in the inner cell mass (ICM) and the trophectoderm (TE) of the human embryo to understand the mechanisms underlying TE commitment. We describe here identification of Hes6, Hey1 and Dll1 as a lineage commitment factor or lineage commitment cooperating factor in embryonic stem cells of the human embryo.
Fields of Study & Subjects
Developmental Biology and Gene Regulation
Pluripotent Stem Cells Research
Genomics and Chromatin Dynamics
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 11 February 2026
- Language
- EN
- Document type
- Preprint