TCF7, TCF7L1, and Lef1 together with TCF21 and TCF15 define a basic TCF requirement in the TE lineage specification program.
Abstract
We measured total transcription in the inner cell mass (ICM) and the trophectoderm (TE) of the human embryo to understand the mechanisms underlying TE commitment. We describe a specific requirement for TCF lineage factors in lineage commitment in embryonic stem cells of the human embryo. TCF15 and TCF21 exerted unique control of trophectoderm fate choice dynamics.
Fields of Study & Subjects
Developmental Biology and Gene Regulation
Pluripotent Stem Cells Research
Wnt/β-catenin signaling in development and cancer
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 11 February 2026
- Language
- EN
- Document type
- Preprint