Igf2 and an IGF2 family non-coding RNA are active in the stem cell to TE differentiation program.
Abstract
We measured total transcription in the inner cell mass (ICM) and the trophectoderm (TE) of the human embryo to understand the mechanisms underlying TE commitment. We describe here discovery of Igf2 as a lineage commitment factor in embryonic stem cells of the human embryo. An IGF2 family non-coding RNA was also a major target of modulation in the stem cell to TE differentiation program.
Fields of Study & Subjects
Pluripotent Stem Cells Research
Developmental Biology and Gene Regulation
Epigenetics and DNA Methylation
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 9 February 2026
- Language
- EN
- Document type
- Preprint