Clinical cure of chronic hepatitis B is associated with priming and perpetuation of hepatic CD4+ T cell responses

This repository contains CyTOF data generated for Jespersen & Avanesyan et al., Clinical cure of chronic hepatitis B is associated with priming and perpetuation of hepatic CD4+ T cell responses (Science Translational Medicine, 2026) https://www.science.org/doi/full/10.1126/scitranslmed.adx1523. Peripheral blood samples were collected from patients with chronic hepatitis B before and after nucleos(t)ide analogue (NA) withdrawal. The file "cytof.tar.gz" contains FCS files corresponding to live CD45⁺ PBMCs isolated from individual patient samples and stained using a 41-marker CyTOF antibody panel targeting surface proteins. The file "HBeAg negative HBV CyTOF sample list.xlsx" provides sample-level metadata. Detailed experimental procedures and data generation methods are described in the associated manuscript.